Healthcare· 2025Q1
Yenidoğan Morbiditelerinin Prematüre Bebeklerde Postnatal Büyüme Geriliği ile İlişkisi
Association of Neonatal Morbidities and Postnatal Growth Faltering in Preterm Neonates
- 9atıf
- Q1SCImago
- 2025yıl
Kısa özet
Çok erken doğan bebeklerde (<32 hafta gestasyonel yaş), bronkopulmoner displazi (BPD), ciddi prematüre retinopatisi (ROP) ve daha uzun süreli solunum desteği/hastane yatışı, hem ciddi (%11 insidans) hem de kompleks (%24 insidans) postnatal büyüme geriliği (PGF) ile ilişkilendirilmiştir.
Yapay zekâ ile başlık ve abstract'tan üretildi; tam metin okunmaz.
Ana noktalar
- Prematüre bebeklerde (<32 hafta GA) ciddi PGF insidansı: %11; Kompleks PGF insidansı: %24.
- Her iki PGF türü de bronkopulmoner displazi (BPD), ciddi prematüre retinopatisi (ROP), daha uzun süreli solunum desteği ve hastane yatışı ile ilişkilidir.
- Ciddi PGF, cerrahi nekrotizan enterokolit ile ilişkilidir (%25'e karşı %1.5, p=0.001).
- Kompleks PGF, ciddi beyin hasarı ile ilişkilidir (%51'e karşı %27, p=0.007).
- Kompleks PGF en erken doğan bebeklerde daha yaygındır; ciddi PGF ise gestasyon yaşına göre küçük (SGA) doğan bebeklerde daha yaygındır.
Yapay zekâ ile başlık ve abstract'tan üretildi; tam metin okunmaz.
Özet (abstract)
Background/Objectives: Postnatal growth faltering (PGF) is a risk factor for adverse neurodevelopment in very preterm neonates. The aim of this retrospective study was to determine which infants’ baseline characteristics, prenatal risk factors and neonatal morbidities are associated with two definitions of PGF: defined as loss of >2 weight z-scores (severe PGF) or as loss of >1 weight, length, and head circumference z-scores between birth and discharge (complex PGF); Methods: 146 premature newborns (<32 weeks of gestational age, <1500 g) were included in the study. Anonymized data including anthropometric measurements (weight, length, and head circumference), perinatal and neonatal data (demographics, maternal morbidities and previous pregnancies, and neonatal and perinatal morbidities) were extracted from the clinical electronic database. Changes in anthropometric age- and sex-specific z-scores using the Fenton 2013 preterm growth charts were calculated to diagnose severe PGF and complex PGF; Results: The incidence of severe PGF was 11% and complex PGF was 24%. Both PGF definitions were associated with bronchopulmonary dysplasia (BPD), severe retinopathy of prematurity (ROP), longer respiratory support, and longer hospital stay. Severe PGF was associated with surgical necrotizing enterocolitis at 25% vs. 1.5%, p = 0.001. Complex PGF was associated with severe brain injury at 51% versus 27%, p = 0.007. Complex PGF was more common in newborns born most prematurely, while severe PGF was more common in newborns born small for gestational age (SGA); Conclusions: Both severe and complex PGF are associated with several important neonatal morbidities, which might explain why growth faltering is associated with suboptimal neurodevelopment. Appropriate early identification of faltered growth may influence medical and nutrition interventions which in turn could improve the outcome of very preterm newborns.
Yazarların özeti; kaynağından alınmıştır. Healthcare, 2025 · DOI ↗
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