Circulation· 2013Q1
Worldwide Epidemiology of Atrial Fibrillation
- 4,527citations
- Q1SCImago
- 2013year
Short summary
In 2010, an estimated 33.5 million people worldwide had atrial fibrillation (AF), with prevalence and incidence increasing from 1990 to 2010, alongside a doubling of AF-associated mortality.
AI-generated from the title and abstract; the full text is not read.
Key points
- An estimated 33.5 million people had AF globally in 2010.
- AF prevalence increased from 569.5 (men) and 359.9 (women) per 100,000 in 1990 to 596.2 (men) and 373.1 (women) per 100,000 in 2010.
- AF incidence rates also rose, with men showing a greater increase (60.7 to 77.5 per 100,000 person-years).
- Mortality associated with AF nearly doubled in both men and women from 1990 to 2010.
- Significant regional differences exist in AF prevalence and data availability.
AI-generated from the title and abstract; the full text is not read.
Abstract
BACKGROUND: The global burden of atrial fibrillation (AF) is unknown. METHODS AND RESULTS: We systematically reviewed population-based studies of AF published from 1980 to 2010 from the 21 Global Burden of Disease regions to estimate global/regional prevalence, incidence, and morbidity and mortality related to AF (DisModMR software). Of 377 potential studies identified, 184 met prespecified eligibility criteria. The estimated number of individuals with AF globally in 2010 was 33.5 million (20.9 million men [95% uncertainty interval (UI), 19.5-22.2 million] and 12.6 million women [95% UI, 12.0-13.7 million]). Burden associated with AF, measured as disability-adjusted life-years, increased by 18.8% (95% UI, 15.8-19.3) in men and 18.9% (95% UI, 15.8-23.5) in women from 1990 to 2010. In 1990, the estimated age-adjusted prevalence rates of AF (per 100 000 population) were 569.5 in men (95% UI, 532.8-612.7) and 359.9 in women (95% UI, 334.7-392.6); the estimated age-adjusted incidence rates were 60.7 per 100 000 person-years in men (95% UI, 49.2-78.5) and 43.8 in women (95% UI, 35.9-55.0). In 2010, the prevalence rates increased to 596.2 (95% UI, 558.4-636.7) in men and 373.1 (95% UI, 347.9-402.2) in women; the incidence rates increased to 77.5 (95% UI, 65.2-95.4) in men and 59.5 (95% UI, 49.9-74.9) in women. Mortality associated with AF was higher in women and increased by 2-fold (95% UI, 2.0-2.2) and 1.9-fold (95% UI, 1.8-2.0) in men and women, respectively, from 1990 to 2010. There was evidence of significant regional heterogeneity in AF estimations and availability of population-based data. CONCLUSIONS: These findings provide evidence of progressive increases in overall burden, incidence, prevalence, and AF-associated mortality between 1990 and 2010, with significant public health implications. Systematic, regional surveillance of AF is required to better direct prevention and treatment strategies.
The authors' abstract, as published at the source. Circulation, 2013 · DOI ↗
Continue with a free account
Ask the paper: 3 free questions a day about this paper; save it, get its citation, new summaries every day for your field. Takeaways are Premium.
Continue free on the webSign in with Google or Apple; no card needed. You come back to this paper.
On your phone:
Field: Cardiology and Cardiovascular Medicine
Cardiology and Cardiovascular MedicineMedicine