Science· 2014Q1· Review
Dialogue between skin microbiota and immunity
- 736citations
- Q1SCImago
- 2014year
Short summary
Skin microbiota and immune cells dynamically interact to maintain skin's physical and immune barrier, adapting to host changes and environmental challenges.
AI-generated from the title and abstract; the full text is not read.
Key points
- Skin acts as a barrier against pathogens while hosting commensal microbes.
- Keratinized skin cells, immune cells, and microbes interact throughout life.
- These interactions regulate skin's physical and immune barrier maintenance.
- The process adapts to host physiological changes and environmental challenges like wounding or infection.
AI-generated from the title and abstract; the full text is not read.
Abstract
Human skin, the body's largest organ, functions as a physical barrier to bar the entry of foreign pathogens, while concomitantly providing a home to myriad commensals. Over a human's life span, keratinized skin cells, immune cells, and microbes all interact to integrate the processes of maintaining skin's physical and immune barrier under homeostatic healthy conditions and also under multiple stresses, such as wounding or infection. In this Review, we explore the intricate interactions of microbes and immune cells on the skin surface and within associated appendages to regulate this orchestrated maturation in the context of both host physiological changes and environmental challenges.
The authors' abstract, as published at the source. Science, 2014 · DOI ↗
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Field: Dermatology
DermatologyMedicine