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Physiological Reviews· 2014Q1· Review

Thyroid Hormone Regulation of Metabolism

Rashmi Mullur, Yan‐Yun Liu, Gregory A. Brent

Short summary

Thyroid hormone (TH) regulates adult metabolism via tissue-specific activation of thyroxine (T4) to triiodothyronine (T3) by 5'-deiodinase type 2 (D2), particularly in tissues like brown adipose tissue (BAT) for thermogenesis.

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Field: Endocrinology, Diabetes and Metabolism

Endocrinology, Diabetes and MetabolismMedicine