The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

Short summary

New definitions for sepsis and septic shock have been established, defining sepsis as life-threatening organ dysfunction due to a dysregulated host response to infection, operationalized by a 2-point increase in SOFA score. Septic shock is now defined by profound circulatory, cellular, and metabolic abnormalities requiring vasopressors and elevated lactate, indicating a mortality risk over 40%.

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