Epidemiology papers
Pofolia’s corpus holds 82 papers from Epidemiology (1996–2026), each with a short summary. Below, the 20 most-cited, then the most recently added.
At a glance
- Most cited: The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) (2016, 28,211 citations).
- The 20 papers listed have 178,213 citations between them.
- 17 of the 18 with a known journal quartile appeared in a Q1 journal.
- 15 have a free full text (open access).
- Most frequent journals: New England Journal of Medicine, Stroke, Hepatology.
- Published between 2013 and 2021.
Most cited
Ranked by citation count. Because citations accumulate over time, this list naturally leans towards work published a few years ago; for where the field is now, see “recently added”. How to read the signals
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
JAMA · 2016 · Q1 · SJR 5.00 · FWCI 1276.82 · 28,211 citations · Open access
New definitions for sepsis and septic shock have been established, defining sepsis as life-threatening organ dysfunction due to a dysregulated host response to infection, operationalized by a 2-point increase in SOFA score. Septic shock is now defined by profound circulatory, cellular, and metabolic abnormalities requiring vasopressors and elevated lactate, indicating a mortality risk over 40%.
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
Cellular Physiology and Biochemistry · 2015 · Q3 · FWCI 1241.52 · 16,339 citations · Open access
Autophagy, a crucial cellular degradation process, is increasingly implicated in the pathology of various ocular diseases.
An interactive web-based dashboard to track COVID-19 in real time
The Lancet Infectious Diseases · 2020 · Q1 · SJR 5.00 · FWCI 1394.55 · 11,178 citations · Open access
A real-time, interactive web dashboard was developed to visualize and track COVID-19 cases, deaths, and recoveries globally, providing a user-friendly tool for researchers, public health officials, and the public.
Global epidemiology of nonalcoholic fatty liver disease—Meta‐analytic assessment of prevalence, incidence, and outcomes
Hepatology · 2015 · Q1 · SJR 7.00 · FWCI 215.90 · 10,847 citations
This meta-analysis estimates that 25.24% of the global population has nonalcoholic fatty liver disease (NAFLD), with significant regional variations and strong associations with metabolic comorbidities.
Surviving Sepsis Campaign
Critical Care Medicine · 2013 · Q1 · SJR 1.00 · FWCI 903.41 · 9,740 citations
Updated guidelines for managing severe sepsis and septic shock emphasize prompt administration of broad-spectrum antimicrobials within 1 hour of recognition and early quantitative resuscitation with crystalloids, aiming for a minimum of 30 mL/kg.
The Metabolic Phenotype in Obesity: Fat Mass, Body Fat Distribution, and Adipose Tissue Function
Obesity Facts · 2017 · Q1 · SJR 1.00 · FWCI 428.24 · 8,487 citations · Open access
Beyond total fat mass, body fat distribution and adipose tissue function are stronger predictors of insulin resistance and related complications in individuals with obesity. Impaired adipose tissue function involves issues like poor expandability, inflammation, and altered lipid metabolism.
Breastfeeding in the 21st century: epidemiology, mechanisms, and lifelong effect
The Lancet · 2016 · FWCI 416.81 · 8,056 citations · Open access
Breastfeeding offers significant lifelong health benefits for both children and mothers, including protection against infections, increased intelligence, and reduced risks of certain cancers and diabetes, even in high-income countries.
Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study
The Lancet · 2020 · FWCI 459.78 · 7,809 citations · Open access
In 2017, sepsis caused an estimated 48.9 million cases and 11.0 million deaths globally, accounting for nearly 20% of all deaths, despite a significant decline in age-standardized incidence and mortality since 1990.
Global, regional, and national burden of stroke and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019
The Lancet Neurology · 2021 · Q1 · SJR 12.00 · FWCI 660.91 · 7,717 citations · Open access
While age-standardized stroke rates decreased globally between 1990-2019, the absolute number of strokes and deaths increased significantly, driven by a rise in younger stroke cases and a growing burden in low-income countries.
Guidelines for the Early Management of Patients With Acute Ischemic Stroke
Stroke · 2013 · Q1 · SJR 2.00 · FWCI 362.06 · 7,660 citations · Open access
New guidelines update recommendations for acute ischemic stroke management within the first 48 hours, emphasizing stroke systems of care and detailing interventions from patient recognition to reperfusion strategies.
Guidelines for the Early Management of Patients With Acute Ischemic Stroke: 2019 Update to the 2018 Guidelines for the Early Management of Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association
Stroke · 2019 · Q1 · SJR 2.00 · FWCI 429.19 · 7,345 citations
These updated guidelines provide comprehensive recommendations for clinicians managing adult patients with acute arterial ischemic stroke, superseding previous 2013 and 2018 versions.
The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases
Hepatology · 2017 · Q1 · SJR 7.00 · FWCI 306.43 · 7,318 citations · Open access
This practice guidance offers a data-supported approach to diagnosing, treating, and preventing nonalcoholic fatty liver disease (NAFLD) for clinicians.
A Randomized Trial of Intraarterial Treatment for Acute Ischemic Stroke
New England Journal of Medicine · 2014 · Q1 · SJR 18.00 · FWCI 383.72 · 6,632 citations · Open access
Intraarterial treatment within 6 hours of stroke onset significantly improved functional outcomes for patients with acute ischemic stroke due to proximal intracranial arterial occlusion.
Cancer treatment and survivorship statistics, 2016
CA A Cancer Journal for Clinicians · 2016 · Q1 · SJR 104.00 · FWCI 672.80 · 6,160 citations
Over 15.5 million Americans were living with a history of cancer as of January 1, 2016, a number projected to exceed 20 million by 2026, highlighting a growing population with unique medical and psychosocial needs.
Randomized Assessment of Rapid Endovascular Treatment of Ischemic Stroke
New England Journal of Medicine · 2015 · Q1 · SJR 18.00 · FWCI 471.85 · 6,063 citations · Open access
Rapid endovascular treatment for acute ischemic stroke patients with proximal vessel occlusion significantly improved functional independence at 90 days (53.0% vs. 29.3%) and reduced mortality (10.4% vs. 19.0%) compared to standard care.
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Autophagy · 2016 · Q1 · SJR 4.00 · FWCI 610.10 · 6,009 citations · Open access
This third edition of guidelines updates best practices for monitoring autophagy, emphasizing the critical distinction between measuring autophagic elements (like autophagosomes) and assessing autophagic flux (the complete process of cargo degradation). The update aims to clarify confusion, especially for researchers new to the field.
Endovascular Therapy for Ischemic Stroke with Perfusion-Imaging Selection
New England Journal of Medicine · 2015 · Q1 · SJR 18.00 · FWCI 454.38 · 5,832 citations · Open access
Early endovascular thrombectomy using the Solitaire FR stent retriever significantly improved reperfusion, early neurologic recovery, and long-term functional outcomes in ischemic stroke patients compared to alteplase alone.
Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
The Lancet Neurology · 2019 · Q1 · SJR 12.00 · FWCI 370.10 · 5,731 citations · Open access
Neurological disorders are the leading cause of disability worldwide, accounting for 276 million disability-adjusted life-years (DALYs) in 2016, and are the second leading cause of death. Despite decreasing age-standardized rates, the absolute number of deaths and DALYs from these disorders increased significantly between 1990 and 2016.
Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct
New England Journal of Medicine · 2017 · Q1 · SJR 18.00 · FWCI 309.38 · 5,574 citations · Open access
Endovascular thrombectomy performed 6 to 24 hours after an ischemic stroke significantly improved functional outcomes in patients with a mismatch between clinical deficit and infarct volume.
2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association
Stroke · 2018 · Q1 · SJR 2.00 · FWCI 495.40 · 5,505 citations
This article is a correction to the 2018 guidelines for the early management of acute ischemic stroke.
Recently added
Pneumococcal population structure influences the effects of air pollution on invasive disease risk in South Africa
Nature Microbiology · 2026 · Q1 · SJR 7.00 · FWCI 5.59 · 1 citations
Invasive pneumococcal disease (IPD) risk increased by 5% with moderate humidity (33–49%) and 4% with cold minimum temperatures (4–10 °C) over 8 weeks, while warm maximum temperatures (27–38 °C) increased risk by up to 10% within a week. Air pollution (PM 2.5) also positively associated with IPD, with specific serotypes (4, 8, 23F) and the GPSC21 lineage showing immediate risk following exposure.
Cervical cancer prevention and control strategy in Ethiopia: key informant clinicians’ perspective
Scientific Reports · 2026 · Q1 · FWCI 11.62 · 2 citations · Open access
Ethiopian clinicians report that while health education and VIA/cryotherapy screening are used, key challenges to cervical cancer prevention include low awareness, staff burnout, inconsistent screening, and poor follow-up, especially for HIV-positive women.
A lipid transfer-dependent feedback loop activates ATG9A compartments in autophagy initiation
Nature Communications · 2026 · Q1 · SJR 4.00 · FWCI 17.68 · 3 citations · Open access
Autophagy initiation relies on ATG9A compartments, which are activated by a lipid transfer-driven feedback loop involving ATG2A and ATG8 proteins, enabling PI3P production and phagophore expansion.
2026 Guideline for the Early Management of Patients With Acute Ischemic Stroke: A Guideline From the American Heart Association/American Stroke Association
Stroke · 2026 · Q1 · SJR 2.00 · FWCI 1244.25 · 227 citations
The 2026 AHA/ASA guideline updates acute ischemic stroke management with new evidence on thrombolytic choice, endovascular thrombectomy eligibility, and hyperglycemia/dysphagia management, plus a focus on pediatric patients.
Obeticholic Acid and Other Farnesoid-X-Receptor (FXR) Agonists in the Treatment of Liver Disorders
Pharmaceuticals · 2025 · Q1 · SJR 1.00 · FWCI 19.57 · 31 citations · Open access
Obeticholic acid (OCA), an FXR agonist, has shown promise in treating liver disorders like primary biliary cholangitis (PBC) and metabolic dysfunction-associated steatohepatitis (MASH), but faces challenges due to drug-induced liver injury and marginal efficacy in steatosis.
Therapeutic implications of obeticholic acid, a farnesoid X receptor agonist, in the treatment of liver fibrosis
Biomedicine & Pharmacotherapy · 2025 · Q1 · SJR 2.00 · FWCI 9.22 · 14 citations
Obeticholic acid (OCA), an FXR agonist, shows therapeutic potential for liver fibrosis by modulating bile acid metabolism, inflammation, and lipid profiles, with preclinical and clinical data supporting its use in conditions like primary biliary cholangitis and NASH.
The Role of Autophagy in Excitotoxicity, Synaptic Mitochondrial Stress and Neurodegeneration
Autophagy Reports · 2025 · Q1 · SJR 1.00 · FWCI 7.03 · 11 citations
Autophagy, a cellular cleanup process, can both protect and harm neurons during excitotoxic injury, a condition implicated in stroke, epilepsy, and neurodegeneration.
The effect and safety of obeticholic acid for patients with nonalcoholic steatohepatitis: A systematic review and meta-analysis of randomized controlled trials
Medicine · 2024 · Q2 · FWCI 2.46 · 22 citations
Obeticholic acid (OCA) treatment significantly reduced liver fibrosis (OR: 1.95) and steatosis (OR: 1.95) in nonalcoholic steatohepatitis (NASH) patients, along with improvements in liver enzymes like ALT and AST. However, it also increased total cholesterol and LDL, and pruritus was a common side effect, particularly at higher doses.
Journals in this field
The journals that publish most of this field’s papers. Quartile (Q1–Q4), SJR and h-index are from SCImago Journal Rank; “in this field” is how many of the journal’s pooled papers belong here. What is a Q1 journal? · What is the h-index?
| Journal | Quartile | SJR | h-index | In this field | Summaries |
|---|---|---|---|---|---|
| New England Journal of Medicine | Q1 | 18.00 | 1275 | 11 | 376 |
| Stroke | Q1 | 2.00 | 382 | 7 | 15 |
| Hepatology | Q1 | 7.00 | 424 | 6 | 17 |
| The Lancet Global Health | Q1 | 5.00 | 168 | 4 | 19 |
| The Lancet Neurology | Q1 | 12.00 | 398 | 3 | 12 |
| Autophagy | Q1 | 4.00 | 216 | 3 | 3 |
| Critical Care Medicine | Q1 | 1.00 | 326 | 3 | 7 |
| Journal of Innate Immunity | Q1 | 1.00 | 91 | 3 | 3 |
Every journal in Epidemiology (Q1–Q4) →
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