Key papers in Epidemiology
Pofolia’s corpus holds 71 papers from the Epidemiology subfield (2012–2023). The list below starts with the most cited.
Most cited
Ranked by citation count. Because citations accumulate over time, this list naturally leans towards work published a few years ago; for where the field is now, see “recently added”.
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
JAMA · 2016 · Q1 · SJR 5.00 · FWCI 1276.82 · 28,211 citations · Open access
New definitions for sepsis and septic shock have been established, defining sepsis as life-threatening organ dysfunction due to a dysregulated host response to infection, operationalized by a 2-point increase in SOFA score. Septic shock is now defined by profound circulatory, cellular, and metabolic abnormalities requiring vasopressors and elevated lactate, indicating a mortality risk over 40%.
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
Cellular Physiology and Biochemistry · 2015 · Q3 · FWCI 1241.52 · 16,339 citations · Open access
Autophagy, a crucial cellular degradation process, is increasingly implicated in the pathology of various ocular diseases.
An interactive web-based dashboard to track COVID-19 in real time
The Lancet Infectious Diseases · 2020 · Q1 · SJR 5.00 · FWCI 1394.55 · 11,178 citations · Open access
A real-time, interactive web dashboard was developed to visualize and track COVID-19 cases, deaths, and recoveries globally, providing a user-friendly tool for researchers, public health officials, and the public.
Global epidemiology of nonalcoholic fatty liver disease—Meta‐analytic assessment of prevalence, incidence, and outcomes
Hepatology · 2015 · Q1 · SJR 7.00 · FWCI 215.90 · 10,847 citations
This meta-analysis estimates that 25.24% of the global population has nonalcoholic fatty liver disease (NAFLD), with significant regional variations and strong associations with metabolic comorbidities.
Surviving Sepsis Campaign
Critical Care Medicine · 2013 · Q1 · SJR 1.00 · FWCI 903.41 · 9,740 citations
Updated guidelines for managing severe sepsis and septic shock emphasize prompt administration of broad-spectrum antimicrobials within 1 hour of recognition and early quantitative resuscitation with crystalloids, aiming for a minimum of 30 mL/kg.
The Metabolic Phenotype in Obesity: Fat Mass, Body Fat Distribution, and Adipose Tissue Function
Obesity Facts · 2017 · Q1 · SJR 1.00 · FWCI 428.24 · 8,487 citations · Open access
Beyond total fat mass, body fat distribution and adipose tissue function are stronger predictors of insulin resistance and related complications in individuals with obesity. Impaired adipose tissue function involves issues like poor expandability, inflammation, and altered lipid metabolism.
Breastfeeding in the 21st century: epidemiology, mechanisms, and lifelong effect
The Lancet · 2016 · FWCI 416.81 · 8,056 citations · Open access
Breastfeeding offers significant lifelong health benefits for both children and mothers, including protection against infections, increased intelligence, and reduced risks of certain cancers and diabetes, even in high-income countries.
Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study
The Lancet · 2020 · FWCI 459.78 · 7,809 citations · Open access
In 2017, sepsis caused an estimated 48.9 million cases and 11.0 million deaths globally, accounting for nearly 20% of all deaths, despite a significant decline in age-standardized incidence and mortality since 1990.
Global, regional, and national burden of stroke and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019
The Lancet Neurology · 2021 · Q1 · SJR 12.00 · FWCI 660.91 · 7,717 citations · Open access
While age-standardized stroke rates decreased globally between 1990-2019, the absolute number of strokes and deaths increased significantly, driven by a rise in younger stroke cases and a growing burden in low-income countries.
Guidelines for the Early Management of Patients With Acute Ischemic Stroke
Stroke · 2013 · Q1 · SJR 2.00 · FWCI 362.06 · 7,660 citations · Open access
New guidelines update recommendations for acute ischemic stroke management within the first 48 hours, emphasizing stroke systems of care and detailing interventions from patient recognition to reperfusion strategies.
Guidelines for the Early Management of Patients With Acute Ischemic Stroke: 2019 Update to the 2018 Guidelines for the Early Management of Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association
Stroke · 2019 · Q1 · SJR 2.00 · FWCI 429.19 · 7,345 citations
These updated guidelines provide comprehensive recommendations for clinicians managing adult patients with acute arterial ischemic stroke, superseding previous 2013 and 2018 versions.
The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases
Hepatology · 2017 · Q1 · SJR 7.00 · FWCI 306.43 · 7,318 citations · Open access
This practice guidance offers a data-supported approach to diagnosing, treating, and preventing nonalcoholic fatty liver disease (NAFLD) for clinicians.
A Randomized Trial of Intraarterial Treatment for Acute Ischemic Stroke
New England Journal of Medicine · 2014 · Q1 · SJR 18.00 · FWCI 383.72 · 6,632 citations · Open access
Intraarterial treatment within 6 hours of stroke onset significantly improved functional outcomes for patients with acute ischemic stroke due to proximal intracranial arterial occlusion.
Cancer treatment and survivorship statistics, 2016
CA A Cancer Journal for Clinicians · 2016 · Q1 · SJR 104.00 · FWCI 672.80 · 6,160 citations
Over 15.5 million Americans were living with a history of cancer as of January 1, 2016, a number projected to exceed 20 million by 2026, highlighting a growing population with unique medical and psychosocial needs.
Randomized Assessment of Rapid Endovascular Treatment of Ischemic Stroke
New England Journal of Medicine · 2015 · Q1 · SJR 18.00 · FWCI 471.85 · 6,063 citations · Open access
Rapid endovascular treatment for acute ischemic stroke patients with proximal vessel occlusion significantly improved functional independence at 90 days (53.0% vs. 29.3%) and reduced mortality (10.4% vs. 19.0%) compared to standard care.
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Autophagy · 2016 · Q1 · SJR 4.00 · FWCI 610.10 · 6,009 citations · Open access
This third edition of guidelines updates best practices for monitoring autophagy, emphasizing the critical distinction between measuring autophagic elements (like autophagosomes) and assessing autophagic flux (the complete process of cargo degradation). The update aims to clarify confusion, especially for researchers new to the field.
Endovascular Therapy for Ischemic Stroke with Perfusion-Imaging Selection
New England Journal of Medicine · 2015 · Q1 · SJR 18.00 · FWCI 454.38 · 5,832 citations · Open access
Early endovascular thrombectomy using the Solitaire FR stent retriever significantly improved reperfusion, early neurologic recovery, and long-term functional outcomes in ischemic stroke patients compared to alteplase alone.
Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
The Lancet Neurology · 2019 · Q1 · SJR 12.00 · FWCI 370.10 · 5,731 citations · Open access
Neurological disorders are the leading cause of disability worldwide, accounting for 276 million disability-adjusted life-years (DALYs) in 2016, and are the second leading cause of death. Despite decreasing age-standardized rates, the absolute number of deaths and DALYs from these disorders increased significantly between 1990 and 2016.
Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct
New England Journal of Medicine · 2017 · Q1 · SJR 18.00 · FWCI 309.38 · 5,574 citations · Open access
Endovascular thrombectomy performed 6 to 24 hours after an ischemic stroke significantly improved functional outcomes in patients with a mismatch between clinical deficit and infarct volume.
2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association
Stroke · 2018 · Q1 · SJR 2.00 · FWCI 495.40 · 5,505 citations
This article is a correction to the 2018 guidelines for the early management of acute ischemic stroke.
Recently added
A multisociety Delphi consensus statement on new fatty liver disease nomenclature
Journal of Hepatology · 2023 · Q1 · SJR 13.00 · FWCI 478.96 · 2,764 citations · Open access
A consensus of 236 experts and patient advocates from 56 countries has adopted new nomenclature for fatty liver disease, replacing NAFLD with MASLD (metabolic dysfunction-associated steatotic liver disease) and introducing MetALD (metabolic and alcohol related/associated liver disease).
A multisociety Delphi consensus statement on new fatty liver disease nomenclature
Hepatology · 2023 · Q1 · SJR 7.00 · FWCI 512.01 · 2,959 citations
A Delphi consensus involving 236 experts and patient advocates recommends replacing NAFLD/NASH with 'metabolic dysfunction-associated steatotic liver disease' (MASLD) and 'metabolic dysfunction-associated steatohepatitis' (MASH) to reduce stigma and improve identification. The new definition requires at least one cardiometabolic risk factor.
Physical Activity and Nonalcoholic Fatty Liver Disease: A Roundtable Statement from the American College of Sports Medicine
Medicine & Science in Sports & Exercise · 2023 · Q1 · SJR 1.00 · FWCI 6.51 · 38 citations
Regular physical activity, even without significant weight loss, reduces liver fat and improves body composition, fitness, and quality of life in patients with nonalcoholic fatty liver disease (NAFLD).
American College of Sports Medicine (ACSM) International Multidisciplinary Roundtable report on physical activity and nonalcoholic fatty liver disease
Hepatology Communications · 2023 · Q1 · SJR 2.00 · FWCI 14.07 · 82 citations · Open access
Regular physical activity is strongly linked to decreased NAFLD risk and improved outcomes, including reduced liver fat and better body composition, according to an ACSM roundtable report.
The global epidemiology of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH): a systematic review
Hepatology · 2023 · Q1 · SJR 7.00 · FWCI 211.26 · 3,046 citations
Global NAFLD prevalence is 30.05% and has increased by 50.4% between 1990-2006 and 2016-2019, with Latin America showing the highest regional prevalence (44.37%).
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