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The Lancet· 2014· Review

Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials

Jonathan Emberson, Kennedy R. Lees, Patrick D. Lyden, Lisa Blackwell et al.

Short summary

Alteplase improves good stroke outcomes within 4.5 hours, with benefits decreasing with treatment delay; earlier treatment (within 3 hours) yielded a 32.9% good outcome rate vs. 23.1% for controls (OR 1.75).

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Field: Epidemiology

EpidemiologyMedicine