Neurogastroenterology & Motility· 2012Q1· Review
Intestinal barrier function in health and gastrointestinal disease
- 898citations
- Q1SCImago
- 2012year
Short summary
Defects in intestinal barrier function, characterized by increased permeability, are increasingly implicated in gastrointestinal diseases like IBD, celiac disease, and IBS.
AI-generated from the title and abstract; the full text is not read.
Key points
- Increased intestinal permeability is linked to diseases such as IBD, celiac disease, and IBS.
- The intestinal barrier comprises components like the tight junction complex within the epithelium.
- Methods for assessing gut permeability include both in vitro and in vivo approaches.
- The review examines evidence from animal models and human studies to assess the role of barrier dysfunction in functional GI disorders.
AI-generated from the title and abstract; the full text is not read.
Abstract
Defects in intestinal barrier function are associated with diseases of the gastrointestinal (GI) tract. There is growing evidence that increases in intestinal permeability plays a pathogenic role in diseases, such as inflammatory bowel disease (IBD) and celiac disease, and functional bowel disorders, such as irritable bowel syndrome (IBS). This review takes a unique translational approach to discuss the physiological and pathophysiological mechanisms involved in the regulation of intestinal barrier function in IBS. The review summarizes the components of the intestinal barrier including the tight junction complex within the epithelium, and the methods used to assess gut permeability both in vitro and in vivo. Throughout the review, the authors have attempted to critically review the latest research from both experimental animal models and human studies to appraise whether intestinal barrier dysfunction is a primary cause of functional GI disorders, such as IBS.…
The authors' abstract, as published at the source. Neurogastroenterology & Motility, 2012 · DOI ↗
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Field: Gastroenterology
GastroenterologyMedicine