Systematic review with meta‐analysis: the efficacy of prebiotics, probiotics, synbiotics and antibiotics in irritable bowel syndrome

Short summary

A meta-analysis of 53 randomized controlled trials (RCTs) found that while specific probiotic combinations/strains may benefit IBS symptoms, definitive conclusions on their efficacy are not possible. However, the antibiotic rifaximin demonstrated modest efficacy in improving symptoms for non-constipated IBS patients compared to placebo (RR of symptoms persisting = 0.84; 95% CI 0.79-0.90).

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