Proceedings of the National Academy of Sciences· 2013Q1

Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics

Andrea Sottoriva, Inmaculada Spiteri, Sara Piccirillo, Anestis Touloumis et al.

1,765citations
Q1SCImago
2013year

Short summary

Glioblastoma tumors harbor extensive intratumor heterogeneity, with most patients displaying different GB subtypes within the same tumor, revealed by genomic analysis of spatially distinct fragments.

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Field: Genetics

GeneticsMedicine