Blood· 2018Q1· Review
iwCLL guidelines for diagnosis, indications for treatment, response assessment, and supportive management of CLL
- 1,706citations
- Q1SCImago
- 2018year
Short summary
Updated iwCLL guidelines now incorporate genomic landscape discoveries, prognostic genetic tests, and minimal residual disease (MRD) detection for diagnosis, treatment indications, response assessment, and supportive management of CLL.
AI-generated from the title and abstract; the full text is not read.
Key points
- Guidelines updated to reflect recent advances in CLL research.
- Incorporates genomic landscape discoveries and prognostic genetic tests.
- Revised response criteria and updated guidance on MRD status.
- Includes recommendations for viral disease assessment and prophylaxis during CLL management.
AI-generated from the title and abstract; the full text is not read.
Abstract
The previous edition of the consensus guidelines of the International Workshop on Chronic Lymphocytic Leukemia (iwCLL), published in 2008, has found broad acceptance by physicians and investigators caring for patients with CLL. Recent advances including the discovery of the genomic landscape of the disease, the development of genetic tests with prognostic relevance, and the detection of minimal residual disease (MRD), coupled with the increased availability of novel targeted agents with impressive efficacy, prompted an international panel to provide updated evidence- and expert opinion-based recommendations. These recommendations include a revised version of the iwCLL response criteria, an update on the use of MRD status for clinical evaluation, and recommendations regarding the assessment and prophylaxis of viral diseases during management of CLL.
The authors' abstract, as published at the source. Blood, 2018 · DOI ↗
Continue with a free account
Ask the paper: 3 free questions a day about this paper; save it, get its citation, new summaries every day for your field. Takeaways are Premium.
Continue free on the webSign in with Google or Apple; no card needed. You come back to this paper.
On your phone:
Field: Genetics (Medicine)
GeneticsMedicine