Cancer Cell· 2017Q1· Review

Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma

Alan Mackay, Anna Burford, Diana Carvalho, Elisa Izquierdo et al.

1,263citations
Q1SCImago
2017year

Short summary

An integrated analysis of over 1,000 pediatric high-grade gliomas and diffuse intrinsic pontine gliomas identified co-segregating mutations in histone-mutant subgroups, including loss of FBXW7 in H3.3G34R/V, TOP3A rearrangements in H3.3K27M, and BCOR mutations in H3.1K27M.

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Field: Genetics

GeneticsMedicine