PubMed· 2014· Review
Review on iron and its importance for human health.
- 1,491citations
- 2014year
Short summary
Iron is crucial for oxygen transport, DNA synthesis, and electron transport, but its excess can cause tissue damage due to free radical formation, leading to common metabolic disorders like anemia and iron overload.
AI-generated from the title and abstract; the full text is not read.
Key points
- Iron is essential for oxygen transport, DNA synthesis, and electron transport.
- Excess iron can cause tissue damage via free radical formation.
- Iron metabolism disorders are common, including anemia and iron overload.
- This review covers iron metabolism, bioavailability, requirements, deficiency, and prevention strategies.
AI-generated from the title and abstract; the full text is not read.
Abstract
It is well-known that deficiency or over exposure to various elements has noticeable effects on human health. The effect of an element is determined by several characteristics, including absorption, metabolism, and degree of interaction with physiological processes. Iron is an essential element for almost all living organisms as it participates in a wide variety of metabolic processes, including oxygen transport, deoxyribonucleic acid (DNA) synthesis, and electron transport. However, as iron can form free radicals, its concentration in body tissues must be tightly regulated because in excessive amounts, it can lead to tissue damage. Disorders of iron metabolism are among the most common diseases of humans and encompass a broad spectrum of diseases with diverse clinical manifestations, ranging from anemia to iron overload, and possibly to neurodegenerative diseases. In this review, we discuss the latest progress in studies of iron metabolism and bioavailability, and our current understanding of human iron requirement and consequences and causes of iron deficiency. Finally, we discuss strategies for prevention of iron deficiency.
The authors' abstract, as published at the source. PubMed, 2014 · DOI ↗
Continue with a free account
Ask the paper: 3 free questions a day about this paper; save it, get its citation, new summaries every day for your field. Takeaways are Premium.
Continue free on the webSign in with Google or Apple; no card needed. You come back to this paper.
On your phone:
Field: Hematology
HematologyMedicine