Physiological Reviews· 2013Q1· Review
Systemic Iron Homeostasis
- 1,108citations
- Q1SCImago
- 2013year
Short summary
The iron hormone hepcidin and its receptor ferroportin regulate iron absorption and recycling, determining total body iron content.
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Key points
- Hepcidin and ferroportin control the primary fluxes of iron into plasma: intestinal absorption and macrophage recycling.
- Total body iron content is determined by iron absorption, regulated by hepcidin and ferroportin, as body iron losses are minimal.
- Hepcidin is regulated by plasma iron, iron stores, and erythrocyte precursor activity.
- Hepcidin synthesis is induced by inflammatory signals such as interleukin-6 and activin B.
AI-generated from the title and abstract; the full text is not read.
Abstract
The iron hormone hepcidin and its receptor and cellular iron exporter ferroportin control the major fluxes of iron into blood plasma: intestinal iron absorption, the delivery of recycled iron from macrophages, and the release of stored iron from hepatocytes. Because iron losses are comparatively very small, iron absorption and its regulation by hepcidin and ferroportin determine total body iron content. Hepcidin is in turn feedback-regulated by plasma iron concentration and iron stores, and negatively regulated by the activity of erythrocyte precursors, the dominant consumers of iron. Hepcidin and ferroportin also play a role in host defense and inflammation, and hepcidin synthesis is induced by inflammatory signals including interleukin-6 and activin B. This review summarizes and discusses recent progress in molecular characterization of systemic iron homeostasis and its disorders, and identifies areas for further investigation.
The authors' abstract, as published at the source. Physiological Reviews, 2013 · DOI ↗
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Field: Hematology
HematologyMedicine