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Journal of Clinical Oncology· 2012Q1

Multicenter, Randomized, Open-Label, Phase III Trial of Decitabine Versus Patient Choice, With Physician Advice, of Either Supportive Care or Low-Dose Cytarabine for the Treatment of Older Patients With Newly Diagnosed Acute Myeloid Leukemia

Hagop M. Kantarjian, Xavier Thomas, Anna Dmoszyńska, Agnieszka Wierzbowska et al.

Short summary

Decitabine improved complete remission (CR) plus CR without platelet recovery (CRp) rates by 17.8% versus 7.8% in older AML patients (odds ratio 2.5, P=.001), with similar safety to standard treatment choice (TC).

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Field: Hematology

HematologyMedicine