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New England Journal of Medicine· 2013Q1· Clinical trial

Sofosbuvir for Previously Untreated Chronic Hepatitis C Infection

Eric Lawitz, Alessandra Mangia, David Wyles, M. Rodríguez‐Torres et al.

Short summary

A 12-week sofosbuvir-based regimen achieved a 90% sustained virologic response rate in previously untreated patients with Hepatitis C genotypes 1, 4, 5, or 6. In a separate trial, sofosbuvir plus ribavirin was non-inferior to standard therapy for genotypes 2 or 3, with fewer adverse events.

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Field: Hepatology

HepatologyMedicine