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New England Journal of Medicine· 2014Q1

Ledipasvir and Sofosbuvir for 8 or 12 Weeks for Chronic HCV without Cirrhosis

Kris V. Kowdley, Stuart C. Gordon, K. Rajender Reddy, Lorenzo Rossaro et al.

Short summary

An 8-week treatment of ledipasvir-sofosbuvir achieved a 94% sustained virologic response rate in previously untreated HCV genotype 1 patients without cirrhosis, demonstrating noninferiority to a 12-week regimen and showing no additional benefit from ribavirin.

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Field: Hepatology

HepatologyMedicine