The Journal of Dermatology· 2026Q1
Tissue Olink Proteomics Analysis Reveals CCL17 as a Potential Biomarker in Patients With Pressure Ulcers
- 0citations
- Q1SCImago
- 2026year
Short summary
CCL17 protein expression is decreased in pressure ulcer (PU) tissues, suggesting it as a novel potential biomarker for PU pathogenesis and prognosis.
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Key points
- CCL17 was identified as a potential biomarker for pressure ulcers (PUs).
- Olink Inflammation Panel analysis found 16 differentially expressed proteins between PU and normal tissues.
- CCL17 showed the largest fold change and a diagnostic AUC of 0.75.
- Immunohistochemistry and western blotting confirmed decreased CCL17 expression in PU tissues.
AI-generated from the title and abstract; the full text is not read.
Abstract
ABSTRACT Pressure ulcer (PU) typically arises as a chronic cutaneous ulcer stemming from a complex interplay of factors. However, the underlying mechanisms of this condition remain unclear. The aim of this study was to identify inflammatory biomarkers in patients with PU. In this study, PU and normal tissues were collected from 24 patients with PU. An exploratory Olink Inflammation Panel analysis was performed to identify candidate differentially expressed proteins (DEPs) between PU and normal tissue samples from 16 of the 24 patients with PU. A total of 16 candidate DEPs were identified using an unadjusted p < 0.05 threshold between the two groups. Among them, CCL17 had the largest fold change and diagnostic potential with an optimal AUC value (0.75). In addition, CCL17, ANGPT1, FASLG, and VEGFA demonstrated high clinical relevance in the patients with PU. Immunohistochemistry and western blotting using PU tissues obtained from the remaining 8 patients confirmed the decreased expression of CCL17 in PU tissues. In conclusion, CCL17 is a novel potential biomarker for PU pathogenesis and prognosis.
The authors' abstract, as published at the source. The Journal of Dermatology, 2026 · DOI ↗
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Field: Occupational Therapy
Occupational TherapyHealth Professions