World Allergy Organization Journal· 2020Q1
IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper
- 544citations
- Q1SCImago
- 2020year
Short summary
Skin prick testing remains the first-line diagnostic approach for suspected allergic conditions, with serum specific IgE and basophil activation tests offering added value in specific contexts.
AI-generated from the title and abstract; the full text is not read.
Key points
- Skin prick testing is the recommended first-line diagnostic method for IgE sensitization.
- Serum specific IgE tests (to whole extracts or components) and basophil activation tests have an evaluated added value.
- The paper distinguishes between allergic sensitization and clinical allergy, where symptoms must be present.
- Unproven and non-validated diagnostic tests are also discussed.
AI-generated from the title and abstract; the full text is not read.
Abstract
Currently, testing for immunoglobulin E (IgE) sensitization is the cornerstone of diagnostic evaluation in suspected allergic conditions. This review provides a thorough and updated critical appraisal of the most frequently used diagnostic tests, both in vivo and in vitro. It discusses skin tests, challenges, and serological and cellular in vitro tests, and provides an overview of indications, advantages and disadvantages of each in conditions such as respiratory, food, venom, drug, and occupational allergy. Skin prick testing remains the first line approach in most instances; the added value of serum specific IgE to whole allergen extracts or components, as well as the role of basophil activation tests, is evaluated. Unproven, non-validated, diagnostic tests are also discussed. Throughout the review, the reader must bear in mind the relevance of differentiating between sensitization and allergy; the latter entails not only allergic sensitization, but also clinically relevant symptoms triggered by the culprit allergen.
The authors' abstract, as published at the source. World Allergy Organization Journal, 2020 · DOI ↗
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Field: Immunology and Allergy
Immunology and AllergyMedicine