Cancers· 2018Q1· Review
Cancer-Associated Thrombosis: An Overview of Mechanisms, Risk Factors, and Treatment
- 634citations
- Q1SCImago
- 2018year
Short summary
Cancer patients face a significantly higher risk of venous thromboembolism (VTE) due to cancer cells activating coagulation and anticancer treatments promoting thrombosis.
AI-generated from the title and abstract; the full text is not read.
Key points
- Cancer-associated thrombosis, mainly VTE, is a major cause of death in cancer patients.
- Risk factors like chemotherapy and immobility increase VTE risk in cancer patients.
- Cancer cells activate the coagulation cascade, contributing to thrombosis.
- Anticancer treatments can act as additional mechanisms promoting VTE.
AI-generated from the title and abstract; the full text is not read.
Abstract
Cancer-associated thrombosis is a major cause of mortality in cancer patients, the most common type being venous thromboembolism (VTE). Several risk factors for developing VTE also coexist with cancer patients, such as chemotherapy and immobilisation, contributing to the increased risk cancer patients have of developing VTE compared with non-cancer patients. Cancer cells are capable of activating the coagulation cascade and other prothrombotic properties of host cells, and many anticancer treatments themselves are being described as additional mechanisms for promoting VTE. This review will give an overview of the main thrombotic complications in cancer patients and outline the risk factors for cancer patients developing cancer-associated thrombosis, focusing on VTE as it is the most common complication observed in cancer patients. The multiple mechanisms involved in cancer-associated thrombosis, including the role of anticancer drugs, and a brief outline of the current treatment for cancer-associated thrombosis will also be discussed.
The authors' abstract, as published at the source. Cancers, 2018 · DOI ↗
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Field: Internal Medicine
Internal MedicineMedicine