Journal of Cutaneous Pathology· 2026Q2
Acute Myeloid Leukemia Involving the Skin
- 0citations
- Q2SCImago
- 2026year
Short summary
Cutaneous infiltration by acute myeloid leukemia (AML) blasts, known as leukemia cutis (LC), frequently shows immunophenotypic discordance with bone marrow blasts and recurrent genetic associations, impacting diagnosis and prognosis.
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Key points
- Leukemia cutis (LC) is the infiltration of skin by leukemic cells, most commonly AML in adults.
- LC can precede, coincide with, or follow bone marrow involvement.
- AML-associated LC frequently shows immunophenotypic discordance with bone marrow blasts.
- Specific genetic associations are recurrent in AML-associated LC.
- Diagnostic challenges arise due to histopathologic overlap with inflammatory dermatoses.
AI-generated from the title and abstract; the full text is not read.
Abstract
ABSTRACT Leukemia cutis (LC) refers to cutaneous infiltration by leukemic cells, most often by acute myeloid leukemia (AML) in adults and by lymphoblastic leukemia in children. Although uncommon, LC is a clinically significant manifestation of extramedullary disease and may precede, coincide with, or follow bone marrow involvement. Recognition of AML‐associated LC is essential, as it can be diagnostically challenging due to histopathologic overlap with inflammatory dermatoses and other cutaneous hematolymphoid neoplasms. Recent cohort‐based studies have systematically characterized AML involving the skin, demonstrating frequent immunophenotypic discordance between cutaneous and marrow blasts and recurrent genetic associations, with important diagnostic and prognostic implications for dermatopathologists. This review provides a practical framework for current and historical nomenclature, the diagnosis of cutaneous AML, and key histopathologic patterns and pitfalls.
The authors' abstract, as published at the source. Journal of Cutaneous Pathology, 2026 · DOI ↗
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