New England Journal of Medicine· 2012Q1
Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia
- 6,043citations
- Q1SCImago
- 2012year
Short summary
A new coronavirus, HCoV-EMC, was isolated from a fatal pneumonia case in Saudi Arabia, showing significant similarity to SARS and close genetic relation to bat coronaviruses.
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Key points
- A novel coronavirus (HCoV-EMC) was isolated from a patient with fatal pneumonia and renal failure in Saudi Arabia.
- The virus replicated readily in cell culture, causing characteristic cytopathic effects.
- HCoV-EMC is classified as a new betacoronavirus species, with bat coronaviruses HKU4 and HKU5 as its closest known relatives.
- The clinical presentation was similar to SARS, underscoring the risk of severe disease from animal coronaviruses in humans.
AI-generated from the title and abstract; the full text is not read.
Abstract
A previously unknown coronavirus was isolated from the sputum of a 60-year-old man who presented with acute pneumonia and subsequent renal failure with a fatal outcome in Saudi Arabia. The virus (called HCoV-EMC) replicated readily in cell culture, producing cytopathic effects of rounding, detachment, and syncytium formation. The virus represents a novel betacoronavirus species. The closest known relatives are bat coronaviruses HKU4 and HKU5. Here, the clinical data, virus isolation, and molecular identification are presented. The clinical picture was remarkably similar to that of the severe acute respiratory syndrome (SARS) outbreak in 2003 and reminds us that animal coronaviruses can cause severe disease in humans.
The authors' abstract, as published at the source. New England Journal of Medicine, 2012 · DOI ↗
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Field: Infectious Diseases
Infectious DiseasesMedicine