Proceedings of the National Academy of Sciences· 2020Q1
Cell entry mechanisms of SARS-CoV-2
- 3,460citations
- Q1SCImago
- 2020year
Short summary
SARS-CoV-2 enters human cells via its spike protein binding to hACE2, with its RBD showing higher affinity than SARS-CoV, but paradoxically less exposure. Crucially, SARS-CoV-2 entry is pre-activated by furin, unlike SARS-CoV, reducing reliance on target cell proteases.
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Infectious DiseasesMedicine