Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV

Short summary

SARS-CoV-2 uses human ACE2 as its receptor and enters cells primarily via endocytosis, with PIKfyve, TPC2, and cathepsin L being critical for this process. The SARS-CoV-2 spike protein is less stable than SARS-CoV's, and antibodies or sera from recovered SARS or COVID-19 patients show limited cross-neutralization.

AI-generated from the title and abstract; the full text is not read.