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AIChE Journal· 2026Q1

Making imprinted polymers work in water: Engineering interfaces for better resveratrol separation

Chen Yang, Hongyan Zhang, Wanqi Du, Zijian Zhang et al.

Short summary

Engineered hydrophilic interfaces on resveratrol-imprinted polymers (MIPs) using epoxide ring-opening improved adsorption capacity to 43.14 mg g⁻¹ and an imprinting factor of 2.08 in water, overcoming traditional hydrophobic limitations.

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Key points

  • Interfacial hydrophilicity of resveratrol-imprinted polymers (MIPs) was engineered via epoxide ring-opening.
  • Surface wettability was tunable, with water contact angles (WCA) spanning 124.4°–19.9°.
  • An optimal amphiphilic balance (WCA = 52.5°) using zwitterionic glycine yielded a high adsorption capacity of 43.14 mg g⁻¹ and an imprinting factor of 2.08.
  • Molecular dynamics simulations indicated a hydration shield mechanism for selective resveratrol capture.

AI-generated from the title and abstract; the full text is not read.

Abstract

Abstract The practical application of molecularly imprinted polymers (MIPs) in aqueous separations is critically hindered by an inherent trade‐off between binding capacity and selectivity, stemming from non‐specific hydrophobic interactions. Addressing this challenge, this work establishes a robust structure–performance relationship by precisely engineering the interfacial hydrophilicity of resveratrol‐imprinted microspheres via epoxide ring‐opening. Systematically varying the modification chemistry achieved wide‐range tunability of surface wettability, with water contact angles (WCA) spanning 124.4°–19.9°. An optimal amphiphilic balance (WCA = 52.5°) using zwitterionic glycine delivered a high adsorption capacity of 43.14 mg g −1 and an imprinting factor of 2.08 under competitive aqueous conditions. Supported by molecular dynamics (MD) simulations, the optimized interface fosters a synergistic hydration shield, effectively repelling interfering species while facilitating targeted resveratrol capture. Our findings resolve the critical capacity‐selectivity paradox, providing a generalizable paradigm for developing high‐performance separation materials for complex aqueous streams in bio‐processing and pharmaceutical wastewater treatment.

The authors' abstract, as published at the source. AIChE Journal, 2026 · DOI ↗

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Field: Analytical Chemistry

Analytical ChemistryChemistry