Nature Communications· 2020Q1
Transplacental transmission of SARS-CoV-2 infection
- 1,119citations
- Q1SCImago
- 2020year
Short summary
SARS-CoV-2 can be transmitted from mother to fetus, causing placental infection, maternal and neonatal viremia, and neurological compromise in the neonate.
AI-generated from the title and abstract; the full text is not read.
Key points
- SARS-CoV-2 can cross the placenta from mother to fetus.
- Placental infection was confirmed by immunohistochemistry and histology, showing high viral load and inflammation.
- The neonate exhibited neurological symptoms consistent with adult SARS-CoV-2 infections.
AI-generated from the title and abstract; the full text is not read.
Abstract
SARS-CoV-2 outbreak is the first pandemic of the century. SARS-CoV-2 infection is transmitted through droplets; other transmission routes are hypothesized but not confirmed. So far, it is unclear whether and how SARS-CoV-2 can be transmitted from the mother to the fetus. We demonstrate the transplacental transmission of SARS-CoV-2 in a neonate born to a mother infected in the last trimester and presenting with neurological compromise. The transmission is confirmed by comprehensive virological and pathological investigations. In detail, SARS-CoV-2 causes: (1) maternal viremia, (2) placental infection demonstrated by immunohistochemistry and very high viral load; placental inflammation, as shown by histological examination and immunohistochemistry, and (3) neonatal viremia following placental infection. The neonate is studied clinically, through imaging, and followed up. The neonate presented with neurological manifestations, similar to those described in adult patients.
The authors' abstract, as published at the source. Nature Communications, 2020 · DOI ↗
Continue with a free account
Ask the paper: 3 free questions a day about this paper; save it, get its citation, new summaries every day for your field. Takeaways are Premium.
Continue free on the webSign in with Google or Apple; no card needed. You come back to this paper.
On your phone:
Field: Obstetrics and Gynecology
Obstetrics and GynecologyMedicine