Journal of Clinical Investigation· 2017Q1

IFN-γ–related mRNA profile predicts clinical response to PD-1 blockade

Mark Ayers, Jared Lunceford, Michael Nebozhyn, Erin Murphy et al.

3,903citations
Q1SCImago
2017year

Short summary

A T cell-inflamed gene expression profile (GEP) derived from baseline tumor samples predicts response to PD-1 blockade across nine cancer types, outperforming PD-L1 immunohistochemistry in head and neck cancer.

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Field: Oncology

OncologyMedicine