Annual Review of Biomedical Engineering· 2018Q1· Review
Bone Mechanical Properties in Healthy and Diseased States
- 989citations
- Q1SCImago
- 2018year
Short summary
Bone's mechanical properties, crucial for movement and protection, decline with aging and diseases like osteoporosis and diabetes, impacting quality of life.
AI-generated from the title and abstract; the full text is not read.
Key points
- Bone's mechanical integrity is vital for skeletal function and organ protection.
- Aging and diseases like osteoporosis and diabetes lead to deterioration in bone mechanical properties.
- The review covers bone mechanics from nanoscale to macroscale, encompassing material behaviors like elasticity, yield, fracture, fatigue, and damage.
- Both bone quantity (density, porosity) and bone quality (cross-linking, protein composition) are critical determinants of mechanical performance.
AI-generated from the title and abstract; the full text is not read.
Abstract
The mechanical properties of bone are fundamental to the ability of our skeletons to support movement and to provide protection to our vital organs. As such, deterioration in mechanical behavior with aging and/or diseases such as osteoporosis and diabetes can have profound consequences for individuals' quality of life. This article reviews current knowledge of the basic mechanical behavior of bone at length scales ranging from hundreds of nanometers to tens of centimeters. We present the basic tenets of bone mechanics and connect them to some of the arcs of research that have brought the field to recent advances. We also discuss cortical bone, trabecular bone, and whole bones, as well as multiple aspects of material behavior, including elasticity, yield, fracture, fatigue, and damage. We describe the roles of bone quantity (e.g., density, porosity) and bone quality (e.g., cross-linking, protein composition), along with several avenues of future research.
The authors' abstract, as published at the source. Annual Review of Biomedical Engineering, 2018 · DOI ↗
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Field: Orthopedics and Sports Medicine
Orthopedics and Sports MedicineMedicine