Neurology· 2015Q1
International consensus diagnostic criteria for neuromyelitis optica spectrum disorders
- 4,578citations
- Q1SCImago
- 2015year
Short summary
New diagnostic criteria for neuromyelitis optica spectrum disorders (NMOSD) have been established, unifying the term and stratifying diagnoses based on the presence of aquaporin-4 IgG antibodies (AQP4-IgG).
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Key points
- Unified term 'neuromyelitis optica spectrum disorders' (NMOSD) established.
- NMOSD diagnoses are now stratified by AQP4-IgG antibody status.
- Criteria include broader clinical syndromes and MRI findings for optic nerve, spinal cord, and other CNS areas.
- Consensus reached on pediatric NMOSD diagnosis and related concepts.
AI-generated from the title and abstract; the full text is not read.
Abstract
Neuromyelitis optica (NMO) is an inflammatory CNS syndrome distinct from multiple sclerosis (MS) that is associated with serum aquaporin-4 immunoglobulin G antibodies (AQP4-IgG). Prior NMO diagnostic criteria required optic nerve and spinal cord involvement but more restricted or more extensive CNS involvement may occur. The International Panel for NMO Diagnosis (IPND) was convened to develop revised diagnostic criteria using systematic literature reviews and electronic surveys to facilitate consensus. The new nomenclature defines the unifying term NMO spectrum disorders (NMOSD), which is stratified further by serologic testing (NMOSD with or without AQP4-IgG). The core clinical characteristics required for patients with NMOSD with AQP4-IgG include clinical syndromes or MRI findings related to optic nerve, spinal cord, area postrema, other brainstem, diencephalic, or cerebral presentations. More stringent clinical criteria, with additional neuroimaging findings, are required for diagnosis of NMOSD without AQP4-IgG or when serologic testing is unavailable. The IPND also proposed validation strategies and achieved consensus on pediatric NMOSD diagnosis and the concepts of monophasic NMOSD and opticospinal MS.
The authors' abstract, as published at the source. Neurology, 2015 · DOI ↗
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Field: Pathology and Forensic Medicine
Pathology and Forensic MedicineMedicine