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Science· 2012Q1

Synaptic Dysfunction in Depression: Potential Therapeutic Targets

Ronald S. Duman, George K. Aghajanian

Short summary

Ketamine rapidly reverses stress-induced synaptic deficits and produces antidepressant effects within hours, highlighting synaptogenesis as a key mechanism for mood regulation and treatment response.

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Field: Pharmacology

PharmacologyMedicine