International Journal of Molecular Sciences· 2019Q1· Review
The Therapeutic Potential of Apigenin
- 1,213citations
- Q1SCImago
- 2019year
Short summary
Apigenin, a flavonoid found in plants, demonstrates broad therapeutic potential across various chronic diseases, including diabetes, neurodegenerative disorders, depression, and cancer, as supported by in vivo research.
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Key points
- Apigenin, a flavonoid, shows therapeutic promise for multiple chronic diseases.
- In vivo research supports apigenin's benefits in diabetes, neurodegenerative diseases, mood disorders, and cancer.
- The review covers apigenin's chemistry, nutraceutical features, and dietary assessment applications.
- Data from public databases are used to evaluate apigenin's role in diet and health effects.
AI-generated from the title and abstract; the full text is not read.
Abstract
Several plant bioactive compounds have exhibited functional activities that suggest they could play a remarkable role in preventing a wide range of chronic diseases. The largest group of naturally-occurring polyphenols are the flavonoids, including apigenin. The present work is an updated overview of apigenin, focusing on its health-promoting effects/therapeutic functions and, in particular, results of in vivo research. In addition to an introduction to its chemistry, nutraceutical features have also been described. The main key findings from in vivo research, including animal models and human studies, are summarized. The beneficial indications are reported and discussed in detail, including effects in diabetes, amnesia and Alzheimer's disease, depression and insomnia, cancer, etc. Finally, data on flavonoids from the main public databases are gathered to highlight the apigenin's key role in dietary assessment and in the evaluation of a formulated diet, to determine exposure and to investigate its health effects in vivo.
The authors' abstract, as published at the source. International Journal of Molecular Sciences, 2019 · DOI ↗
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Field: Pharmacology (Medicine)
PharmacologyMedicine