Current Issues in Molecular Biology· 2026Q2
Therapeutic Potential of Hydrogen Sulfide in Bone Deficiency
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- 2026year
Short summary
Hydrogen sulfide (H2S) supplementation shows therapeutic potential for bone deficiency diseases, with exogenous H2S demonstrating bone-protective effects in animal models by reducing inflammation, acting as an antioxidant, and regulating bone metabolic balance.
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Key points
- Exogenous H2S supplementation demonstrates bone-protective effects in animal models of bone deficiency.
- Therapeutic mechanisms include anti-inflammatory and antioxidant activities, and regulation of bone metabolic balance.
- H2S modulates osteoclast generation/activation, osteoblast differentiation, and mesenchymal stem cell function.
- Key signaling pathways involved are RANKL/OPG, Wnt/β-catenin, and p38-MAPK.
AI-generated from the title and abstract; the full text is not read.
Abstract
H2S, recognized as the third gaseous signaling molecule following NO and CO, holds significant potential for therapeutic applications in diseases characterized by bone deficiency. Considerable advancements have been achieved in the development of bone scaffold materials incorporating H2S donors, as well as in the creation of innovative H2S-releasing pharmacological agents. Exogenous supplementation of H2S has exhibited pronounced bone-protective effects in animal models of osteoporosis, fractures, and periodontitis. These therapeutic effects are mediated through various mechanisms, including anti-inflammatory and antioxidant activities, alongside the bidirectional regulation of bone metabolic balance. Mechanistically, H2S plays a critical role throughout the entire bone remodeling process—encompassing the resorption, reversal, and formation phases—by modulating osteoclast generation and activation, osteoblast differentiation and maturation, and maintaining mesenchymal stem cell function. This modulation occurs via key signaling pathways, such as the RANKL/OPG, the Wnt/β-catenin, and the p38-MAPK signaling pathway. A deeper understanding of the role of H2S in bone deficiency can lead to the discovery of new therapeutic targets, while innovative H2S donors offer highly promising new treatments for patients with bone deficiency.
The authors' abstract, as published at the source. Current Issues in Molecular Biology, 2026 · DOI ↗
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Field: Biochemistry (Biochemistry, Genetics and Molecular Biology)
BiochemistryBiochemistry, Genetics and Molecular Biology