New England Journal of Medicine· 2012Q1

Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

Randall J. Bateman, Chengjie Xiong, Tammie L.S. Benzinger, Anne M. Fagan et al.

3,848citations
Q1SCImago
2012year

Short summary

In autosomal dominant Alzheimer's disease, key pathological changes begin decades before symptom onset, with amyloid-beta levels dropping 25 years prior and brain metabolism impairment appearing 10 years before.

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Field: Psychiatry and Mental health

Psychiatry and Mental healthMedicine