Scientific Reports· 2018Q1

In situ immune response and mechanisms of cell damage in central nervous system of fatal cases microcephaly by Zika virus

Raimunda do Socorro da Silva Azevedo, Jorge Rodrigues de Sousa, Marialva Tereza Ferreira de Araújo, Arnaldo Jorge Martins Filho et al.

3,566citations
Q1SCImago
2018year

Short summary

Fatal Zika virus (ZIKV) microcephaly cases show complex in situ immune responses in the CNS, with Th2 cytokines predominant but other Th subsets also involved, alongside calcification, necrosis, neuronophagy, gliosis, microglial nodules, and mononuclear cell infiltration.

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Field: Public Health, Environmental and Occupational Health

Public Health, Environmental and Occupational HealthMedicine