Cell Death and Disease· 2020Q1· Review
Ferroptosis: past, present and future
- 4,134citations
- Q1SCImago
- 2020year
Short summary
Ferroptosis is a newly discovered, iron-dependent form of cell death characterized by lipid peroxidation and reduced antioxidant capacity. It is increasingly linked to numerous diseases, making its regulation a key area for therapeutic development.
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Key points
- Ferroptosis is an iron-dependent cell death pathway.
- It involves significant lipid peroxidation and reduced antioxidant capacity.
- Ferroptosis is implicated in diseases like cancer, neurological disorders, and organ injury.
- Regulating ferroptosis is a growing focus for etiological research and treatment development.
AI-generated from the title and abstract; the full text is not read.
Abstract
Ferroptosis is a new type of cell death that was discovered in recent years and is usually accompanied by a large amount of iron accumulation and lipid peroxidation during the cell death process; the occurrence of ferroptosis is iron-dependent. Ferroptosis-inducing factors can directly or indirectly affect glutathione peroxidase through different pathways, resulting in a decrease in antioxidant capacity and accumulation of lipid reactive oxygen species (ROS) in cells, ultimately leading to oxidative cell death. Recent studies have shown that ferroptosis is closely related to the pathophysiological processes of many diseases, such as tumors, nervous system diseases, ischemia-reperfusion injury, kidney injury, and blood diseases. How to intervene in the occurrence and development of related diseases by regulating cell ferroptosis has become a hotspot and focus of etiological research and treatment, but the functional changes and specific molecular mechanisms of ferroptosis still need to be further explored. This paper systematically summarizes the latest progress in ferroptosis research, with a focus on providing references for further understanding of its pathogenesis and for proposing new targets for the treatment of related diseases.
The authors' abstract, as published at the source. Cell Death and Disease, 2020 · DOI ↗
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Field: Pulmonary and Respiratory Medicine
Pulmonary and Respiratory MedicineMedicine