Respiration· 2013Q2
High Performance of <sup>18</sup>F-Fluorodeoxyglucose Positron Emission Tomography and Contrast-Enhanced CT in a Rapid Outpatient Diagnostic Program for Patients with Suspected Lung Cancer
- 4,004citations
- Q2SCImago
- 2013year
Short summary
A rapid outpatient diagnostic program (RODP) using combined <sup>18</sup>F-FDG-PET/CT achieved 97.7% sensitivity and 85.8% accuracy in diagnosing lung cancer in patients with suspicious chest X-rays.
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Key points
- The RODP using <sup>18</sup>F-FDG-PET/CT achieved 97.7% sensitivity, 60.2% specificity, and 85.8% accuracy in diagnosing lung cancer.
- In 386 patients, 260 were diagnosed with lung cancer, 23 with other malignancies, and 78 with benign disease.
- Lung cancer patients experienced median referral, diagnostic, and therapeutic delays of 7, 2, and 19 days, respectively.
- The program successfully differentiated lung cancer from benign disease in patients with abnormal chest X-rays.
AI-generated from the title and abstract; the full text is not read.
Abstract
BACKGROUND: The diagnostic evaluation of patients presenting with possible lung cancer is often complex and time consuming. A rapid outpatient diagnostic program (RODP) including (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) and contrast-enhanced computed tomography (CT) as a routine diagnostic tool may improve timeliness, however the diagnostic performance of such a combined approach of RODP remains unclear. OBJECTIVES: We evaluated timeliness of care and diagnostic performance of FDG-PET and contrast-enhanced CT (FDG-PET/CT) in an RODP for all patients referred with a chest X-ray suspicious of lung cancer. METHODS: Charts of patients referred to the 2-day RODP of our tertiary care university clinic after an abnormal chest X-ray between 1999 and 2009 were reviewed. Between 1999 and 2005 co-registered FDG-PET and CT imaging took place; from September 2005 onwards, a hybrid system was used. We analyzed timeliness of care and diagnostic performance of FDG-PET/CT to differentiate malignant from benign lesions. RESULTS: In 386 patients available for analysis, 260 were diagnosed with lung cancer and 23 had another type of malignancy; in 78 patients benign disease was confirmed, and in another 45 the diagnosis was not pathologically confirmed but a median 24.5-month follow-up confirmed a benign outcome. Sensitivity, specificity, negative and positive predictive values and accuracy of FDG-PET/CT to differentiate lung cancer from benign disease were 97.7, 60.2, 92.5, 84.0 and 85.8%, respectively. Lung cancer patients had a median referral, diagnostic and therapeutic delay of 7, 2 and 19 days, respectively. CONCLUSIONS: FDG-PET/CT in an RODP setting for suspected lung cancer has high performance in detecting cancer and facilitates timely care.
The authors' abstract, as published at the source. Respiration, 2013 · DOI ↗
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Field: Pulmonary and Respiratory Medicine
Pulmonary and Respiratory MedicineMedicine