Nature· 2013Q1
Comprehensive molecular characterization of clear cell renal cell carcinoma
- 3,559citations
- Q1SCImago
- 2013year
Short summary
Analysis of over 400 clear cell renal cell carcinoma (ccRCC) tumors reveals 19 significantly mutated genes, including frequent mutations in the PI(3)K/AKT pathway, suggesting it as a therapeutic target. Aggressive ccRCC shows a metabolic shift involving TCA cycle downregulation and pentose phosphate pathway upregulation, correlating with tumor stage and severity.
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