Organometallics· 2026Q2
A Nickel Pre-Catalyst for the O -Arylation of Primary, Secondary, and Tertiary Alcohols with (Hetero)aryl Chlorides
- 1citations
- Q2SCImago
- 2026year
Short summary
A new, easily prepared, air-stable nickel pre-catalyst, (L2)Ni(4-CN-Ph)Cl, efficiently couples primary, secondary, and tertiary alcohols with (hetero)aryl chlorides.
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Key points
- A single nickel pre-catalyst, (L2)Ni(4-CN-Ph)Cl, is effective for O-arylation of primary, secondary, and tertiary alcohols.
- The pre-catalyst is easily prepared and air-stable.
- The reaction couples alcohols with (hetero)aryl chlorides.
- The catalyst shows useful reaction scope across all alcohol classes.
AI-generated from the title and abstract; the full text is not read.
Abstract
Abstract While base metal-catalyzed cross-couplings of alcohols and (hetero)aryl chlorides have emerged over the past decade, the development of a single pre-catalyst capable of promoting such transformations spanning all of primary, secondary, and tertiary (aliphatic) alcohols remains an enduring challenge. Herein we disclose the easily prepared, air-stable 4-cyanophenyl pre-catalyst (L2)Ni(4-CN-Ph)Cl (L2 = CgPhen-DalPhos), which is shown to be capable of promoting, with useful reaction scope, the C–O cross-coupling of all such alcohol classes with (hetero)aryl chlorides.
The authors' abstract, as published at the source. Organometallics, 2026 · DOI ↗
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Field: Organic Chemistry
Organic ChemistryChemistry