Chemical Reviews· 2016Q1· Review
Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release
- 2,940citations
- Q1SCImago
- 2016year
Short summary
This review details how polymer degradation mechanisms (hydrolysis, oxidation, enzymatic cleavage) dictate drug release kinetics in controlled-release systems, particularly polymeric nanoparticles.
AI-generated from the title and abstract; the full text is not read.
Key points
- Polymer degradation is the primary mechanism for controlled drug release in many systems.
- Key degradation pathways include hydrolysis (ester, amide bonds), oxidation, and enzymatic cleavage.
- The choice of polymer backbone and functional groups dictates the dominant degradation mechanism and release profile.
- Polymeric nanoparticles offer a versatile platform for exploiting these degradation mechanisms for targeted and sustained drug delivery.
AI-generated from the title and abstract; the full text is not read.
Abstract
[Image: see text]
The authors' abstract, as published at the source. Chemical Reviews, 2016 · DOI ↗
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