Journal of Nutrition and Metabolism· 2012Q1· Review
Creatine-Kinase- and Exercise-Related Muscle Damage Implications for Muscle Performance and Recovery
- 753citations
- Q1SCImago
- 2012year
Short summary
Elevated blood creatine kinase (CK) levels after exercise may not always indicate significant muscle damage, as nonmodifiable factors like age, ethnicity, and gender can influence enzyme activity.
AI-generated from the title and abstract; the full text is not read.
Key points
- Blood creatine kinase (CK) is generally considered an indirect marker of muscle damage.
- There is controversy regarding CK's validity in reflecting exercise-induced muscle damage.
- Nonmodifiable factors (ethnicity, age, gender) affect CK tissue activity and serum levels.
- Acceptable upper limits of normal CK levels may need to be reset to account for these factors.
AI-generated from the title and abstract; the full text is not read.
Abstract
The appearance of creatine kinase (CK) in blood has been generally considered to be an indirect marker of muscle damage, particularly for diagnosis of medical conditions such as myocardial infarction, muscular dystrophy, and cerebral diseases. However, there is controversy in the literature concerning its validity in reflecting muscle damage as a consequence of level and intensity of physical exercise. Nonmodifiable factors, for example, ethnicity, age, and gender, can also affect enzyme tissue activity and subsequent CK serum levels. The extent of effect suggests that acceptable upper limits of normal CK levels may need to be reset to recognise the impact of these factors. There is a need for standardisation of protocols and stronger guidelines which would facilitate greater scientific integrity. The purpose of this paper is to examine current evidence and opinion relating to the release of CK from skeletal muscle in response to physical activity and examine if elevated concentrations are a health concern.
The authors' abstract, as published at the source. Journal of Nutrition and Metabolism, 2012 · DOI ↗
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Field: Rehabilitation
RehabilitationMedicine