The World Journal of Men s Health· 2014Q1· Review
Effect of Oxidative Stress on Male Reproduction
- 1,270citations
- Q1SCImago
- 2014year
Short summary
Oxidative stress, caused by an imbalance of reactive oxygen species (ROS) overwhelming antioxidant defenses, significantly impairs sperm quality and fertilizing capacity, contributing to male infertility.
AI-generated from the title and abstract; the full text is not read.
Key points
- Oxidative stress (OS) is a major contributor to male infertility, affecting roughly half of affected couples.
- Excessive reactive oxygen species (ROS) production overwhelms the body's antioxidant defenses, causing cellular damage.
- ROS attack sperm DNA, lipids, and proteins, leading to impaired sperm quality and fertilizing capacity.
- High ROS levels can cause irreparable alterations, cell death, and a decline in semen parameters.
AI-generated from the title and abstract; the full text is not read.
Abstract
Infertility affects approximately 15% of couples trying to conceive, and a male factor contributes to roughly half of these cases. Oxidative stress (OS) has been identified as one of the many mediators of male infertility by causing sperm dysfunction. OS is a state related to increased cellular damage triggered by oxygen and oxygen-derived free radicals known as reactive oxygen species (ROS). During this process, augmented production of ROS overwhelms the body's antioxidant defenses. While small amounts of ROS are required for normal sperm functioning, disproportionate levels can negatively impact the quality of spermatozoa and impair their overall fertilizing capacity. OS has been identified as an area of great attention because ROS and their metabolites can attack DNA, lipids, and proteins; alter enzymatic systems; produce irreparable alterations; cause cell death; and ultimately, lead to a decline in the semen parameters associated with male infertility. This review highlights the mechanisms of ROS production, the physiological and pathophysiological roles of ROS in relation to the male reproductive system, and recent advances in diagnostic methods; it also explores the benefits of using antioxidants in a clinical setting.
The authors' abstract, as published at the source. The World Journal of Men s Health, 2014 · DOI ↗
Continue with a free account
Ask the paper: 3 free questions a day about this paper; save it, get its citation, new summaries every day for your field. Takeaways are Premium.
Continue free on the webSign in with Google or Apple; no card needed. You come back to this paper.
On your phone:
Field: Reproductive Medicine
Reproductive MedicineMedicine