CA A Cancer Journal for Clinicians· 2011Q1
Photodynamic therapy of cancer: An update
- 5,183citations
- Q1SCImago
- 2011year
Short summary
Photodynamic therapy (PDT), a clinically approved treatment, selectively kills cancer cells by administering a photosensitizer followed by light irradiation, leading to tumor cell death, microvascular damage, and inflammation.
AI-generated from the title and abstract; the full text is not read.
Key points
- PDT is a clinically approved, minimally invasive cancer treatment.
- It involves a photosensitizer and light irradiation to induce selective tumor cell death.
- PDT causes direct tumor cell death, microvascular damage, and local inflammation.
- It is effective for early-stage tumors, prolongs survival in advanced cancers, and improves quality of life.
AI-generated from the title and abstract; the full text is not read.
Abstract
Photodynamic therapy (PDT) is a clinically approved, minimally invasive therapeutic procedure that can exert a selective cytotoxic activity toward malignant cells. The procedure involves administration of a photosensitizing agent followed by irradiation at a wavelength corresponding to an absorbance band of the sensitizer. In the presence of oxygen, a series of events lead to direct tumor cell death, damage to the microvasculature, and induction of a local inflammatory reaction. Clinical studies revealed that PDT can be curative, particularly in early stage tumors. It can prolong survival in patients with inoperable cancers and significantly improve quality of life. Minimal normal tissue toxicity, negligible systemic effects, greatly reduced long-term morbidity, lack of intrinsic or acquired resistance mechanisms, and excellent cosmetic as well as organ function-sparing effects of this treatment make it a valuable therapeutic option for combination treatments. With a number of recent technological improvements, PDT has the potential to become integrated into the mainstream of cancer treatment.
The authors' abstract, as published at the source. CA A Cancer Journal for Clinicians, 2011 · DOI ↗
Continue with a free account
Ask the paper: 3 free questions a day about this paper; save it, get its citation, new summaries every day for your field. Takeaways are Premium.
Continue free on the webSign in with Google or Apple; no card needed. You come back to this paper.
On your phone:
Field: Pulmonary and Respiratory Medicine
Pulmonary and Respiratory MedicineMedicine