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PLoS Biology· 2020Q1

A proteomic atlas of senescence-associated secretomes for aging biomarker development

Nathan Basisty, Abhijit Kale, Ok Hee Jeon, Chisaka Kuehnemann et al.

Short summary

The "SASP Atlas" database identifies hundreds of proteins secreted by senescent cells, revealing that previously known SASP factors were underestimated in complexity, and pinpoints GDF15, STC1, and SERPINs as potential biomarkers that correlate with age in human plasma.

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Field: Rheumatology

RheumatologyMedicine