Case Reports in Nephrology and Dialysis· 2017Q3· Case report
Renal-Limited “Lupus-Like” Nephritis: How Much of a Lupus
- 1,305citations
- Q3SCImago
- 2017year
Short summary
A 5-year-old boy presented with lupus nephritis histopathology but no SLE symptoms or autoantibodies, achieving remission with immunosuppressants.
AI-generated from the title and abstract; the full text is not read.
Key points
- A 5-year-old boy exhibited lupus nephritis histopathology without clinical SLE or autoantibodies.
- Treatment involved corticosteroids, mycophenolate mofetil, and intravenous cyclophosphamide.
- The patient achieved remission with resolved proteinuria and improved kidney function over 2 years.
- This case represents a renal-limited 'lupus-like' glomerulonephritis.
AI-generated from the title and abstract; the full text is not read.
Abstract
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by development of autoantibodies to nuclear and cytoplasmic antigens. A small subset of SLE patients who had the typical clinical features of SLE was reported to show persistently negative antinuclear antibody tests. Our report describes a 5-year-old male who presented with histopathological findings suggestive of lupus nephritis with no clinical signs or symptoms of SLE and negative autoantibodies. He was treated with corticosteroids, mycophenolate mofetil, and monthly intravenous cyclophosphamide. During the 2-year follow-up period, the proteinuria resolved and kidney function improved with continued negative autoantibody workup. This case presents a category of renal-limited "lupus-like" glomerulonephritis which can be challenging to treat and carries a poor prognosis.
The authors' abstract, as published at the source. Case Reports in Nephrology and Dialysis, 2017 · DOI ↗
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Field: Rheumatology
RheumatologyMedicine