Signal Transduction and Targeted Therapy· 2023Q1· Review

Osteoarthritis: pathogenic signaling pathways and therapeutic targets

Qing Yao, Xiaohao Wu, Chu Tao, Weiyuan Gong et al.

1,090citations
Q1SCImago
2023year

Short summary

This review details key signaling pathways (Wnt/β-catenin, NF-κB, focal adhesion, HIFs, TGFβ/BMP, FGF) and regulators (AMPK, mTOR, RUNX2) implicated in osteoarthritis (OA) pathogenesis, highlighting their roles in the chronic degenerative joint disorder.

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Field: Rheumatology

RheumatologyMedicine