Arthritis Research & Therapy· 2017Q1
Synovitis in osteoarthritis: current understanding with therapeutic implications
- 1,072citations
- Q1SCImago
- 2017year
Short summary
Synovial inflammation (synovitis) is a prevalent feature in osteoarthritis (OA), appearing even before cartilage damage, and is linked to pain, poor function, and disease progression.
AI-generated from the title and abstract; the full text is not read.
Key points
- Synovitis is a common finding in all stages of osteoarthritis (OA).
- Synovial inflammation can occur before significant cartilage degeneration is visible.
- Synovitis is associated with increased pain and poorer function in OA patients.
- Synovitis may be an independent factor in the onset and progression of OA.
AI-generated from the title and abstract; the full text is not read.
Abstract
Modern concepts of osteoarthritis (OA) have been forever changed by modern imaging phenotypes demonstrating complex and multi-tissue pathologies involving cartilage, subchondral bone and (increasingly recognized) inflammation of the synovium. The synovium may show significant changes, even before visible cartilage degeneration has occurred, with infiltration of mononuclear cells, thickening of the synovial lining layer and production of inflammatory cytokines. The combination of sensitive imaging modalities and tissue examination has confirmed a high prevalence of synovial inflammation in all stages of OA, with a number of studies demonstrating that synovitis is related to pain, poor function and may even be an independent driver of radiographic OA onset and structural progression. Treating key aspects of synovial inflammation therefore holds great promise for analgesia and also for structure modification. This article will review current knowledge on the prevalence of synovitis in OA and its role in symptoms and structural progression, and explore lessons learnt from targeting synovitis therapeutically.
The authors' abstract, as published at the source. Arthritis Research & Therapy, 2017 · DOI ↗
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Field: Rheumatology
RheumatologyMedicine