The Pediatric Infectious Disease Journal· 2026Q1
HIV-1 Drug Resistance in Mother–Infant Pairs in Southern Mozambique
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- Q1SCImago
- 2026year
Short summary
In early-treated children living with HIV in Mozambique, drug resistance mutations were found in 58.1% of children and 50.0% of mothers, with 30% of pairs sharing mutations.
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Key points
- Drug resistance mutations detected in 58.1% of early-treated children with HIV.
- Drug resistance mutations detected in 50.0% of mothers of early-treated children with HIV.
- 30% of mother-infant pairs shared HIV drug resistance mutations.
- No integrase inhibitor resistance mutations were found.
- Mortality rate was 20.3% among the studied children.
AI-generated from the title and abstract; the full text is not read.
Abstract
This prospective nested cohort (EARTH) study evaluated drug resistance mutations and outcomes among 79 (31 with genetic results) early-treated Mozambican children living with HIV, followed for 50 months. Mortality reached 20.3%. Drug resistance mutations were detected in 58.1% of children and 50.0% of mothers; 30% of pairs shared mutations. No integrase inhibitor resistance was detected, supporting Mozambique’s transition to dolutegravir-based regimens.
The authors' abstract, as published at the source. The Pediatric Infectious Disease Journal, 2026 · DOI ↗
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Field: Infectious Diseases
Infectious DiseasesMedicine