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American Journal of Transplantation· 2013Q1

Multicenter Validation of Urinary CXCL9 as a Risk-Stratifying Biomarker for Kidney Transplant Injury

Donald E. Hricik, Peter Nickerson, Richard N. Formica, Emilio D. Poggio et al.

Short summary

Urinary CXCL9 mRNA and protein levels effectively diagnose acute rejection (AR) in kidney transplant recipients, with protein showing higher accuracy (OR 3.40, PPV 67.6%, NPV 92%). Low CXCL9 protein post-transplant predicts a low risk of future AR or declining kidney function.

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Field: Transplantation

TransplantationMedicine