International Journal of Molecular Sciences· 2020Q1· Review
Platelet-Rich Plasma: New Performance Understandings and Therapeutic Considerations in 2020
- 950citations
- Q1SCImago
- 2020year
Short summary
Platelet-rich plasma (PRP) therapy, utilizing autologous cellular therapies, shows potential for tissue repair in musculoskeletal disorders, osteoarthritis, and chronic wounds by leveraging platelet growth factors.
AI-generated from the title and abstract; the full text is not read.
Key points
- PRP therapy uses autologous cellular components to aid tissue repair.
- Platelet growth factors are key to supporting inflammation, proliferation, and remodeling phases of healing.
- Recent research explores PRP bioformulation, platelet dosing, and leukocyte immunomodulation.
- The review covers PRP's role in inflammation, angiogenesis, and interactions with drugs and rehabilitation.
AI-generated from the title and abstract; the full text is not read.
Abstract
Emerging autologous cellular therapies that utilize platelet-rich plasma (PRP) applications have the potential to play adjunctive roles in a variety of regenerative medicine treatment plans. There is a global unmet need for tissue repair strategies to treat musculoskeletal (MSK) and spinal disorders, osteoarthritis (OA), and patients with chronic complex and recalcitrant wounds. PRP therapy is based on the fact that platelet growth factors (PGFs) support the three phases of wound healing and repair cascade (inflammation, proliferation, remodeling). Many different PRP formulations have been evaluated, originating from human, in vitro, and animal studies. However, recommendations from in vitro and animal research often lead to different clinical outcomes because it is difficult to translate non-clinical study outcomes and methodology recommendations to human clinical treatment protocols. In recent years, progress has been made in understanding PRP technology and the concepts for bioformulation, and new research directives and new indications have been suggested. In this review, we will discuss recent developments regarding PRP preparation and composition regarding platelet dosing, leukocyte activities concerning innate and adaptive immunomodulation, serotonin (5-HT) effects, and pain killing. Furthermore, we discuss PRP mechanisms related to inflammation and angiogenesis in tissue repair and regenerative processes. Lastly, we will review the effect of certain drugs on PRP activity, and the combination of PRP and rehabilitation protocols.
The authors' abstract, as published at the source. International Journal of Molecular Sciences, 2020 · DOI ↗
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Field: Urology
UrologyMedicine