Hyaluronic Acid Versus Platelet-Rich Plasma: A Prospective, Double-Blind Randomized Controlled Trial Comparing Clinical Outcomes and Effects on Intra-articular Biology for the Treatment of Knee Osteoarthritis

Short summary

In a randomized controlled trial (n=99), platelet-rich plasma (PRP) injections showed no difference in WOMAC pain scores compared to hyaluronic acid (HA) for knee osteoarthritis, but led to significantly better IKDC scores (65.5 vs 55.8 at 24 weeks) and lower VAS pain scores (34.6 vs 48.6 at 24 weeks) at 24 and 52 weeks.

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